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Cytokines (particularly IL-2, IL-4 and IL-13, which show increased expression in bronchial biopsy specimens from patients with steroid-resistant asthma) may induce a reduction in the affinity of GRs in inflammatory cells such as T-lymphocytes, resulting in local resistance to the anti-inflammatory actions of corticosteroids 68. None of the above authors have any conflicts of interest to disclose.
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